侯四化，博士生导师，课题组组长，长聘教轨副教授，国家海外高层次引进人才（青年项目），上海市海外高层次引进人才，䇹政学者导师。2010年本科毕业于兰州大学化学化工学院，2015年于兰州大学获得理学博士学位，导师涂永强院士。2015年至2017年在新葡的京集团350vip8888官网从事博士后研究，合作导师为张书宇教授。2017年至2021年在芝加哥大学（The University of Chicago）从事博士后研究，合作导师为董广彬 (Dong Guangbin)教授。2021年6月全职加入新葡的京集团350vip8888官网。致力于具有重要生物活性或药用价值天然产物的合成与功能研究。

研究方向：
1、微量活性天然产物的不对称合成
2、天然药物分子的规模化合成
3、目标分子导向的新型高效合成方法学研究
4、抗肿瘤、抗炎、免疫调节候选药物分子的研发

主持与参与基金：
国家自然科学基金委员会，面上基金项目，多环二倍半萜Niduterpenoids A-B和Niduenes A-B、E-F的发散式全合成研究，2025-01至2028-12，50万元，主持，在研
国家科技部，重点研发计划，新型氮杂螺环胺超结构仿酶催化剂的创制与催化，2023-2028，参与，在研
国家自然科学基金委员会，优秀青年科学基金项目（海外），活性天然产物的合成与功能研究，2022-01至2024-12，主持，在研。
国家自然科学基金委员会，青年基金项目，Cephalotaxus类二萜天然产物的全合成，2017-01至2019-12，21万元，主持，已结题。

课题组网站：https://www.x-mol.com/groups/hou_sihua

代表性论文:
1. J. Am. Chem. Soc. 2024, 146, 25445−25450.
2. J. Am. Chem. Soc. 2023, 145, 21170–21175.
3. J. Am. Chem. Soc. 2022, 144, 22159
4. Angew. Chem. Int. Ed. 2022, 61, e202207088
5. Angew. Chem. Int. Ed. 2021, 60, 13057
6. J. Am. Chem. Soc. 2020, 142, 13180
7. Angew. Chem. Int. Ed. 2020, 59, 7848
8. Angew. Chem. Int. Ed. 2016, 55, 4456
9. Angew. Chem. Int. Ed. 2013, 52, 11373

课题组成员：博士后：李权哲 博士（22年入站，获上海市“超级博士后”资助），庄庆博 博士（23年入站），练鹏飞 博士（24年入站）
博士研究生：薛远(23级，联培)，高珠鹏（22级），单兴钱（23级，硕博连读），柯天(联培)，周风帆（24级，硕博连读）
硕士研究生：朱蓉（22级），张祥（23级），胡婧涵（23级），张梦佳（24级）
本科生：孙一航（21级，获22年“䇹政项目”资助并顺利结题）

离组人员：
尹君杰，2022.2-2023.7在组，联培博士生，目前在上海有机所做博士后

欢迎对科学有热情的本科生、硕士生和博士生加入实验室开展课题研究。实验室面向国内外招聘博士后，年薪30-35万元，感兴趣的同学可以发邮件咨询。

实验室：新葡的京集团350vip8888官网七号楼500, 514室；办公室：新葡的京集团350vip8888官网七号楼502室。

课题组主要围绕以下三个问题开展科学研究：
1. 如何实现活性天然物质经济、高效的合成？
2. 如何优化临床复杂药物分子的合成工艺？
3. 如何利用具有复杂三维结构的活性天然分子开展新药研发？

21) Tian Ke, Si-Hua Hou*, Yun-Peng Wang, Kun Fang, Jing-Han Hu, Ka Lu, Yongqiang Tu*
Divergent Total Syntheses of Six Crinipellin-Type Diterpenoids through Tandem 4π-Electrocyclization/ Dicycloexpansion.
Angew. Chem. Int. Ed. 2025, anie.202501008
20) Yuan Xue, Si-Hua Hou*, Xiang Zhang, Fu-Min Zhang, Xiao-Ming Zhang, Yong-Qiang Tu*
Total Synthesis of the Hexacyclic Sesterterpenoid Niduterpenoid B via Structural Reorganization Strategy.
J. Am. Chem. Soc. 2024, 146, 25445−25450
19) Kun Fang, Bao-Heng Dou, Fu-Min Zhang*, Yun-Peng Wang, Zi-Rui Shan, Xiao-Yu Wang, Si-Hua Hou, Yong-Qiang Tu*, Tong-Mei Ding,
Expansion of Structure Property in Cascade Nazarov Cyclization and Cycloexpansion Reaction to Diverse Angular Tricycles and Total Synthesis of Nominal Madreporanone
Angew. Chem. Int. Ed. 2025, 63, anie.202412337
18) Jun-Jie Yin, Yun-Peng Wang, Jun Xue, Feng-Fan Zhou, Xing-Qian Shan, Rong Zhu, Kun Fang, Lei Shi*, Shu-Yu Zhang, Si-Hua Hou*, Wujiong Xia, and Yong-Qiang Tu*
Total Syntheses of Polycyclic Diterpenes Phomopsene, Methyl Phomopsenonate, and iso-Phomopsene via Reorganization of C–C Single Bonds.
J. Am. Chem. Soc. 2023, 145, 21170–21175.
17) Si-Hua Hou,# Xuan Yu,# Rui Zhang, Cole Wagner, Guangbin Dong,* Rhodium-Catalyzed Diastereo- and Enantioselective Divergent Annulations between Cyclobutanones and 1,5-Enynes: Rapid Construction of Complex C(sp3)‑Rich Scaffolds,
J. Am. Chem. Soc. 2022, 144, 22159 – 22169.
16) Quan-Zhe Li,# Si-Hua Hou,# Jin-Chen Kang, Peng-Fei Lian, Yu Hao, Chao Chen, Jia Zhou, Tong-Mei Ding, Shu-Yu Zhang*. Bioinspired Palladium-Catalyzed Intramolecular C(sp3)−H Activation for the Collective Synthesis of Proline Natural Products
Angew. Chem. Int. Ed. 2022, 61, e202207088.


Before SJTU:
15) Si-Hua Hou, Adriana Y. Prichina, Guangbin Dong,* Deconstructive Asymmetric Total Synthesis of Morphine-Family Alkaloid (-)-Thebainone A,
Angew. Chem. Int. Ed. 2021, 60, 13057 – 13064.
14) Si-Hua Hou, Xuan Yu, Rui Zhang, Lin Deng, Mengxi Zhang, Adriana Y. Prichina, Guangbin Dong,* Enantioselective Intramolecular Type II-Cycloaddition of Alkynes via C−C Activation of Cyclobutanones: Rapid and Asymmetric Construction of [3.3.1] Bridged Bicycles,
J. Am. Chem. Soc. 2020, 142, 13180-13189.
13) Si-Hua Hou, Adriana Y. Prichina, Mengxi Zhang, Guangbin Dong,* Asymmetric Total Syntheses of Di- and Sesqui-Terpenoids via Catalytic C–C Activation of Cyclopentanones,
Angew. Chem. Int. Ed. 2020, 59, 7848 – 7856.
12) Wei Jiang, Jia Zhou, Ai-Jun Ma, Dongli Li, Yanyan Ma, Deng-Gao Zhao, Si-Hua Hou, Jun-Bing Lin, Shu-Yu Zhang*, Dienamine-Mediated Deconjugative Addition/Cyclization Cascade of γ, γ-Disubstituted Enals with Carboxylic Acid-Activated Enones: A Rapid Access to Highly Functionalized γ-Lactones,
Org. Chem. Front., 2020,7, 571-577.
11) Quan-Zhe Li, Xun-Hui Wang, Si-Hua Hou, Yan-Yan Ma, Deng-Gao Zhao, Shu-Yu Zhang*, He-Yuan Bai, Tong-Mei Ding, Silver-Catalyzed para-Selective C–H Amination of 1-Naphthylamides with Azodicarboxylates at Room Temperature,
Synthesis, 2019, 51, 2697-2704.
10) Jia Zhou, Guo-Dong Zhu, Le Wang, Fu-Xin Tan, Wei Jiang, Zhi-Gang Ma, Jun-Chen Kang, Si-Hua Hou, Shu-Yu Zhang*, Remote C6-Enantioselective C–H Functionalization of 2, 3-Disubstituted Indoles through the Dual H-Bonds and π–π Interaction Strategy Enabled by CPAs,
Org. Lett. 2019, 21, 8662-8666.
9) Le Wang, Jia Zhou, Tong-Mei Ding, Zhi-Qiang Yan, Si-Hua Hou, Guo-Dong Zhu, Shu-Yu Zhang*, Asymmetric N-Hydroxyalkylation of Indoles with Ethyl Glyoxalates Catalyzed by a Chiral Phosphoric Acid: Highly Enantioselective Synthesis of Chiral N,O-Aminal Indole Derivatives,
Org. Lett. 2019, 21, 2795-2799.
8) Lin Liu, Hai-Long Cheng, Wen-Qiang Ma, Si-Hua Hou, Yong-Qiang Tu*, Fu-Min Zhang, Xiao-Ming Zhang, Shao-Hua Wang, Improved synthesis of 8-oxabicyclo [3.2. 1] octanes via tandem C–H oxidation/oxa-[3, 3] Cope rearrangement/aldol cyclization,
Chem. Comm. 2018, 54, 196-199.
7) Ting-Yu Zhang, Jun-Bing Lin, Quan-Zhe Li, Jun-Chen Kang, Jin-Long Pan, Si-Hua Hou, Chao Chen, Shu-Yu Zhang*, Copper-Catalyzed Selective ortho-C–H/N–H Annulation of Benzamides with Arynes: Synthesis of Phenanthridinone Alkaloids,
Org. Lett. 2017, 19, 1764-1767.
6) Jin-Long Pan, Quan-Zhe Li, Ting-Yu Zhang, Si-Hua Hou, Jun-Cheng Kang, Shu-Yu Zhang*, Palladium-catalyzed direct intermolecular silylation of remote unactivated C (sp 3)–H bonds,
Chem. Comm. 2016, 52, 13151-13154.
5) Si-Hua Hou, Yong-Qiang Tu,* Shuang-Hu Wang, Chao-Chao Xi, Fu-Min Zhang, Shao-Hua Wang, Yan-Tao Li, Lin Liu, Total Syntheses of the Tetracyclic Cyclopiane Diterpenes Conidiogenone, Conidiogenol, and Conidiogenone B,
Angew. Chem. Int. Ed. 2016, 55, 4456-4460.
4) Si-Hua Hou, Yong-Qiang Tu,* Lin Liu, Fu-Min Zhang, Shao-Hua Wang,* XiaoMing Zhang, Divergent and Efficient Syntheses of the Lycopodium Alkaloids (-)-Lycojaponicumin C, (-)-8-Deoxyserratinine, (+)-Fawcettimine, and (+)-Fawcettidine,
Angew. Chem. Int. Ed. 2013, 52, 11373 –11376.
3) Fu-Min Zhang, Lei Peng, Hui Li, Ai-Jun Ma, Jin-Bao Peng, Jing-Jing Guo, Dengtao Yang, Si-Hua Hou, Yong-Qiang Tu,* William Kitching, Total Synthesis of the Nominal Didemnaketal A,
Angew. Chem. Int. Ed. 2012, 51, 10846 –10850.
2) Ai-Jun Ma, Yong-Qiang Tu,* Jin-Bao Peng, Qing-Yun Dou, Si-Hua Hou, Fu-Min Zhang, Shao-Hua Wang, Total Synthesis of (-)-FR901483,
Org. Lett. 2012, 14, 3604-3607.
1) Dong Wang, Jihui Li, Na Li, Tingting Gao, Sihua Hou, Baohua Chen*, An efficient approach to homocoupling of terminal alkynes: Solvent-free synthesis of 1, 3-diynes using catalytic Cu (II) and base,
Green Chem. 2010, 12, 45-48.

围绕若干复杂的多环活性天然产物合成开展系列研究，采用多样性、骨架重构策略，快速、高效地完成了20余个具有重要药用价值的萜类、生物碱的全合成，在J. Am. Chem. Soc.，Angew. Chem. Int. Ed. 等期刊发表二十余篇学术论文，授权中国发明专利2项。获得国家自然科学基金委面上基金，青年基金（已结题），中国博士后国际交流计划派出项目等资助。入选2021年国家海外高层次引进人才（青年项目），2021年上海市海外高层次引进人才计划。