1.Kaige Yang , Mengqi Jia , Soumia Cheddah , Zhouyi Zhang , Weiwei Wang XinYan Li* (共同通讯作者), Yan Wang* , Chao Yan . Peptide ligand-SiO2 microspheres with specific affinity for phosphatidylserine as a new strategy to isolate exosomes and application in proteomics to differentiate hepatic cancer. Bioact Mater. 2022 Sep; 15: 343–354.
2.Meng-YanDeng, Khalil AliAhmad, Qiao-QiaoHan, Zi-YingWang, Rana MuhammadShoaib, Xin-YanLi* (共同通讯作者), Yong-XiangWang*(2021). Thalidomide alleviates neuropathic pain through microglial IL-10/β-endorphin signaling pathway. biochemical pharmacology, Volume 192,October 2021,114727
3.Evhy Apryani,Usman Ali,Zi-Ying Wang, Hai-Yun Wu,Xiao-Fang Mao, Khalil Ali Ahmad, Xin-Yan Li* (共同通讯作者),Yong-Xiang Wang *.(2020). The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors. Journal of Neuroinflammation,17:75
4.Li Wang*, Zhi-Tian Gao, Yi-Fei Chen, Xin-Yan Li* (2019).DNA methylation inhibitor 5-aza-2’deoxycytidine modulates endometrial receptivity through upregulating HOXA10 expression. Reproductive Sciences,2019,Vol.26(6) 839-846
5.Li X.-Y*., Mao X.-F., Tang X.-Q., Han Q.-Q., Jiang L.-X., Qiu Y.-M., Dai J. & Wang Y.-X. (2018). Regulation of Gli2 stability by deubiquitinase OTUB2. Biochem. Biophy. Res. Commun. 505: 113-118
6.Li X.-Y., Wu, H.-Y., Mao X.-F., Jiang L.-X*. & Wang Y.-X*. (2017). USP5 promotes tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 protein. Biochem. Biophy. Res. Commun. 492: 48-54
7.Barrow T.M.#, Byun H.-M.#, Li X.# (共同第一作者), Smart C., Wang Y.-X., Zhang Y., Baccarelli A. & Guo L*. (2017). The effect of morphine upon DNA methylation in ten regions of the rat brain. Epigenetics 12:1038-1047
8.Huang Q., Sun M.-L., Chen Y., Li X.-Y. & Wang Y.-X. (2017). Concurrent bulatine A enhances morphine antinociception and inhibits morphine antinociceptive tolerance by indirect activation of spinal κ-opioid receptors. J. Ethnopharmacol. 196:151-159.
9.Huang Q., Sun M.-L., Chen Y., Li X.-Y. & Wang Y.-X. (2017). Concurrent bulatine A enhances morphine antinociception and inhibits morphine antinociceptive tolerance by indirect activation of spinal κ-opioid receptors. J. Ethnopharmacol. 196:151-159.
10.Wei H., Wu H.-Y.,Chen Z., Ma A.-N., Mao X.-F., Li T.-F, Li X.-Y., Wang Y.-X. &Pertovaara A. (2016). Mechanical antihypersensitivity effect induced by repeated spinal administrations of a TRPA1 antagonist or a gap junction decoupler in peripheral neuropathy. Pharmacol. Biochem. Behav. 150-151:57-67.
11.Wei H., Wu H.-Y., Fan H., Li T.-F., Ma A.-N., Li X.-Y., Wang Y.-X. &Pertovaara A. (2016). Potential role of spinal TRPA1 channels in antinociceptive tolerance to spinally administered morphine. Pharmacol. Rep. 68:472-475
12.Xie D.-S., Lu J., Xie J., Cui J.J., Li T.-F., Wang Y.-C., Chen Y., Gong N., Li X.-Y., Fu L. & Wang Y.-X. (2016). Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione as a novel potent D-amino acid oxidase inhibitor. Eur. J. Med. Chem. 117:19-32.
13.Baohui Zheng, Michael DeRan, Xinyan Li, Xuebin Liao, Masaki Fukata, and Xu Wu. (2013). 2 Bromopalmitate Analogues as Activity-Based Probes To Explore Palmitoyl Acyltransferases. J Am ChemSoc, 135(19):7082-5.
14.Wei H., Gong N., Huang J.-L., Fan H., Ma A.-N., Li X.-Y., Wang Y.-X. &Pertovaara A. (2013). Spinal D-amino acid oxidase contributes to mechanical pain hypersensitivity induced by sleep deprivation in the rat. Pharmacol. Biochem. Behav. 111: 30-36
15.Chen X.-L, Li X.-Y., Qian S-.B, Wang Y.-C., Zhang P.-Z., Zhou X.-J. & Wang Y.-X. (2012). Down-regulation of spinal DAAO expression blocks formalin-induced pain. BiochemBiophys Res Commun, 421(3): 501-7, 2012.
16.Yaming Xu, Xinyan Li, Shiyun Zhang, Di Shen, Hong Li, Yue Wu, Yongming Qiu, Yonghua Ji, Fuxue Chen. (2012). Targeting Stat3 suppresses growth of U251 cell-derived tumours in nude mice. Journal of clinical neuroscience, 1:1532-2653, 2012.
专利:
Xu R, Li X. Compositions and methods for preventing and treating liver cirrhosis. (USA)Patent: 20050036988
王永祥,李欣燕,陈晓玲。抑制DAAO基因表达的siRNA及其医药用途。201110287822.9(2011)
主持或参加科研项目及人才计划项目情况:
1、国家自然科学基金委员会, 专项项目, 82341234, 基于湿热伏邪理论研究葛根芩连汤及其加味方通过调控CD8+TRM防治UC的作用机制与物质基础(联合申请B), 2024-01-01 至 2026-12-31, 200万元, 在研, 参与
2. 国家自然科学基金面上项目,81673403、乌头类生物碱反向镇痛药理学研究、2017.01-2020.12、直接费用:54万元、已结题、参加。
3.国家自然科学基金面上项目,81374000、藏药独一味镇痛作用、有效成分和镇痛作用机制的研究、2014/01-2017/12、70 万元、已结题、参加。
4. 国家自然科学基金青年基金项目,81302751、脊髓星形胶质细胞D-型氨基酸氧化酶介导吗啡镇痛耐受的作用及其信号通路研究、2014/01-2016/12、23万元、已结题、主持。
5. 新葡的京集团350vip8888官网, 医工交叉研究基金, YG2023QNA44 , 探索高蛋白饮食对提高齐拉西酮治疗精神分裂症疗效的机制研究, 2023-01 至 2025-12, 25万元, 在研, 参与
6、新葡的京集团350vip8888官网, 医工交叉研究基金, YG2023QNA25, 基于循环外泌体代谢和蛋白多组学的胆管癌生物标志物筛选研究, 2023-01 至 2025-12, 25万元, 在研, 参与
7、上海市自然科学基金, 11ZR1416400,RNAi 沉默脊髓DAO 基因表达对慢性疼痛发生发展的影响,2011.1-2013.12、10万、已结题、主持。
8、 上海市自然科学基金,04ZR14033,孤儿型甲酰肽样受体2作为药物作用新靶点的研究 2004.1-2006.12、已结题、主持。